Title

Designed 3D DNA Crystals

Abstract

The simplest practical route to producing precisely designed 3D macroscopic objects is to form a crystalline arrangement by self-assembly, because such a periodic array has only conceptually simple requirements: a motif that has a robust 3D structure, dominant affinity interactions between parts of the motif when it self-associates, and predictable structures for these affinity interactions. Fulfilling these three criteria to produce a 3D periodic system is not easy, but should readily be achieved with well-structured branched DNA motifs tailed by sticky ends (Zheng et al., Nature 461:74-77, 2009). Herein, a brief introduction to designed 3D DNA crystals from tensegrity triangle is presented.

Department(s)

Chemistry

Comments

This research has been supported by the following grants to NCS: EFRI-1332411, and CCF-1526650 from the NSF, MURI W911NF-11-1-0024 from ARO, MURI N000140911118 from ONR, DE-SC0007991 from DOE for partial salary support, and grant GBMF3849 from the Gordon and Betty Moore Foundation.

Keywords and Phrases

DNA crystal; Self-assembly

International Standard Book Number (ISBN)

978-1-4939-6452-9

International Standard Serial Number (ISSN)

1064-3745

Document Type

Book - Chapter

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2017 Springer Science+Business Media New York, All rights reserved.

Publication Date

01 Jan 2017

PubMed ID

27812997

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