Designed 3D DNA Crystals
Abstract
The simplest practical route to producing precisely designed 3D macroscopic objects is to form a crystalline arrangement by self-assembly, because such a periodic array has only conceptually simple requirements: a motif that has a robust 3D structure, dominant affinity interactions between parts of the motif when it self-associates, and predictable structures for these affinity interactions. Fulfilling these three criteria to produce a 3D periodic system is not easy, but should readily be achieved with well-structured branched DNA motifs tailed by sticky ends (Zheng et al., Nature 461:74-77, 2009). Herein, a brief introduction to designed 3D DNA crystals from tensegrity triangle is presented.
Recommended Citation
N. C. Seeman et al., "Designed 3D DNA Crystals," Methods in Molecular Biology, vol. 1500, pp. 3 - 10, Humana Press Inc., Jan 2017.
The definitive version is available at https://doi.org/10.1007/978-1-4939-6454-3_1
Department(s)
Chemistry
Keywords and Phrases
DNA crystal; Self-assembly
International Standard Book Number (ISBN)
978-1-4939-6452-9
International Standard Serial Number (ISSN)
1064-3745
Document Type
Book - Chapter
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2017 Springer Science+Business Media New York, All rights reserved.
Publication Date
01 Jan 2017
PubMed ID
27812997
Comments
This research has been supported by the following grants to NCS: EFRI-1332411, and CCF-1526650 from the NSF, MURI W911NF-11-1-0024 from ARO, MURI N000140911118 from ONR, DE-SC0007991 from DOE for partial salary support, and grant GBMF3849 from the Gordon and Betty Moore Foundation.