N-Heterocyclic Carbene-Catalyzed Trifluoromethylation of Aromatic N-Tosylaldimines

Author

Prakash Reddy, Missouri University of Science and TechnologyFollow
Meher Perambuduru
Jatin Mehta

Abstract

Nucleophilic trifluoromethylation of aromatic N-tosylaldimines has been achieved using trifluoromethyltrimethylsilane (TMSCF₃) in the presence of the in situ generated N-heterocyclic carbene catalysts. Aromatic N-tosylaldimines with electron-withdrawing as well as electron-donating groups on the aryl ring afforded the corresponding trifluoromethylated sulfonamides in moderate to good yields.

Recommended Citation

P. Reddy et al., "N-Heterocyclic Carbene-Catalyzed Trifluoromethylation of Aromatic N-Tosylaldimines," Topics in Catalysis, vol. 61, no. 7-8, pp. 699 - 703, Springer US, Jun 2018.

The definitive version is available at https://doi.org/10.1007/s11244-018-0912-7

Department(s)

Chemistry

Keywords and Phrases

Aldimines; Catalysis; Imidazolium; N-Heterocyclic carbene; TMSCF3; Trifluoromethylation

International Standard Serial Number (ISSN)

1022-5528; 1572-9028

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2018 Springer US, All rights reserved.

Publication Date

01 Jun 2018