The Adsorption of Tetracycline and Vancomycin Onto Nanodiamond with Controlled Release
Abstract
The unique properties and tailorable surface of detonation nanodiamonds have given rise to an abundance of potential biomedical applications. Very little is known about the details of adsorption/desorption equilibria of drugs on/from nanodiamonds with different purity, surface chemistry, and agglomeration state. The studies presented here delve into the details of adsorption and desorption of tetracycline (TET) and vancomycin (VAN) on nanodiamond, which are critically important for the rational design of the nanodiamond drug delivery systems. The nanodiamonds studied in these experiments were as-received (ND), purified and carboxyl terminated (ND-COOH), and aminated (ND-NH2). The monolayer capacities of the drugs loaded onto the nanodiamonds are reported herein using Langmuir and Freundlich isotherm models. The results from the desorption studies demonstrate that, by changing the pH environment of drug loaded nanodiamond using buffers of pH 4.09, 7.45, 8.02, and a phosphate buffered saline (PBS) solution, the drug release can effectively be triggered.
Recommended Citation
J. M. Giammarco et al., "The Adsorption of Tetracycline and Vancomycin Onto Nanodiamond with Controlled Release," Journal of Colloid and Interface Science, vol. 468, pp. 253 - 261, Academic Press Inc., Jan 2016.
The definitive version is available at https://doi.org/10.1016/j.jcis.2016.01.062
Department(s)
Chemistry
Research Center/Lab(s)
Center for High Performance Computing Research
International Standard Serial Number (ISSN)
0021-9797
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2016 Academic Press Inc., All rights reserved.
Publication Date
01 Jan 2016