Synthesis, Structure, Spectroscopy and Antitumor Activity of Hydroxy Naphthoquinone Thiosemicarbazone and Its Metal Complexes Against MCF-7 Human Breast Cancer Cell Line
Abstract
Coordinately unsaturated metal complexes of the stoichiometry [M(HL)Cl] and [Fe(HL)Cl 2].2H 2O have been isolated (where M=Cu(II), Ni(II), PD(II) and Pt(II); HL=tridentate anion of H 2L 3). The X-ray crystal structure for 4-hydroxy-3-methyl-1,2-naphthoquinone-1-thiosemicarbazone, 3 has been determined which crystallizes in space group P2 1/c, a = 7.430(3), b = 10.794(3), c = 17.216(5) Å, β =92.91(3)°. Z = 4, and have “E” configuration. The Cu(II) 3a, Ni(II) 3e, Pd(II) 3d and Pt(II) 3e complexes are found to possess square planar geometries, whereas Fe(III) complex 3b possesses a square pyramidal configuration. The in vitro activity of the synthesized compounds examined against human breast cancer cell line MCF-7 clearly indicates that metal complexation enhances antitumor activity, the highest being for the copper complex 3a.
Recommended Citation
D. K. Saha et al., "Synthesis, Structure, Spectroscopy and Antitumor Activity of Hydroxy Naphthoquinone Thiosemicarbazone and Its Metal Complexes Against MCF-7 Human Breast Cancer Cell Line," Indian Journal of Chemistry - Section A Inorganic, Physical, Theoretical and Analytical Chemistry, National Institute of Science Communication and Information Resources (NISCAIR), Jan 2002.
Department(s)
Chemistry
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2002 National Institute of Science Communication and Information Resources (NISCAIR), All rights reserved.
Publication Date
01 Jan 2002
