Stealth Dendrimers for Antiarrhythmic Quinidine Delivery

Abstract

Dendrimers have been attracting growing attention because of their unique well-defined globular nanoscale architecture and numerous functional groups on the surface. Attachment of PEG to the dendrimer generates stealth dendrimers, which have promising structural advantages for drug delivery. In this study, synthetic methods were explored to deliver antiarrhythmic quinidine by stealth dendrimers. In particular, quinidine was covalently attached to anionic G2.5 and cationic G3.0 polyamidoamine (PAMAM) dendrimers via a glycine spacer, respectively. The resulting quinidine-PAMAM-PEG conjugates were characterized and confirmed by FT-IR and 1H-NMR. In vitro hydrolysis was carried out in pH 7.4 PBS buffer at 37°C to confirm the bioavailability of the conjugated quinidine.

Department(s)

Chemical and Biochemical Engineering

Comments

Hu Yang acknowledges the new faculty startup support from the Department of Biomedical Engineering at Virginia Commonwealth University.

Keywords and Phrases

Antiarrhythmic quinidine delivery; Bioavailability; Quinidine-PAMAM-PEG conjugates; Stealth dendrimers, Amino acids; Covalent bonds; Drug delivery; Fourier transform infrared spectroscopy; Functional groups; Hydrolysis; Nuclear magnetic resonance spectroscopy; Polyethylene glycols, Dendrimers, macrogol; polyamidoamine; quinidine; starburst; unclassified drug, article; drug bioavailability; drug delivery system; drug hydrolysis; drug structure; in vitro study; infrared spectroscopy; pH; priority journal; proton nuclear magnetic resonance, Anti-Arrhythmia Agents; Dendrimers; Hydrolysis; Models, Biological; Polyamines; Polyethylene Glycols; Quinidine

International Standard Serial Number (ISSN)

0957-4530; 1573-4838

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2007 Springer Science+Business Media, LLC, All rights reserved.

Publication Date

01 Oct 2007

PubMed ID

17558476

Link to Full Text

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