Folate-Mediated Chemotherapy and Diagnostics: An Updated Review and Outlook
Abstract
Folate receptor (FR) is highly expressed in many types of human cancers, and it has been actively studied for developing targeted chemotherapy and diagnostic agents. Tremendous efforts have been made in developing FR-targeted nanomedicines and nanoprobes and translating them into clinical applications. This article provides a concise review on the latest development of folate-mediated nanomedicines and nanoprobes for chemotherapy and diagnostics with an emphasis on in vivo applications. The cellular uptake mechanisms, pharmacokinetics (PK), administration routes and major challenges in FR-targeted nanoparticles are discussed.
Recommended Citation
L. Xu et al., "Folate-Mediated Chemotherapy and Diagnostics: An Updated Review and Outlook," Journal of Controlled Release, vol. 252, pp. 73 - 82, Elsevier B.V., Apr 2017.
The definitive version is available at https://doi.org/10.1016/j.jconrel.2017.02.023
Department(s)
Chemical and Biochemical Engineering
Keywords and Phrases
Diagnosis; Folate receptor; Folic acid; Nanomedicine; Targeted delivery
International Standard Serial Number (ISSN)
0168-3659; 1873-4995
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2017 Elsevier B.V., All rights reserved.
Publication Date
28 Apr 2017
PubMed ID
28235591
