Fabrication, Characterization, and in Vitro Evaluation of Silver-Containing Arabinoxylan Foams as Antimicrobial Wound Dressing
Arabinoxylan ferulate (AXF) foams were fabricated via enzymatic peroxidase/hydrogen peroxide crosslinking reaction followed by freeze-drying and studied as a potential wound dressing material. The AXF foam's rheological, morphological, porous, and swelling properties were examined. AXF foams were found to be a viscoelastic material that proved to be highly porous and water absorbent. AXF foams possessed low endotoxin levels and were cytocompatible with fibroblasts. Silver was successfully integrated into AXF foams and slowly released over 48 h. AXF foams impregnated with silver demonstrated efficacy inhibiting bacterial growth according to a modified Kirby-Bauer disk diffusion susceptibility test. Overall, AXF foams possess appropriate material properties and the silver-loaded AXF foams showed antimicrobial activity necessary to be a candidate material in wound dressing development.
D. C. Aduba et al., "Fabrication, Characterization, and in Vitro Evaluation of Silver-Containing Arabinoxylan Foams as Antimicrobial Wound Dressing," Journal of Biomedical Materials Research - Part A, vol. 104, no. 10, pp. 2456-2465, John Wiley & Sons Inc., Oct 2016.
The definitive version is available at https://doi.org/10.1002/jbm.a.35783
Chemical and Biochemical Engineering
Keywords and Phrases
arabinoxylan; Kirby-Bauer disk diffusion susceptibility test; polysaccharide; silver dressing; wound healing
International Standard Serial Number (ISSN)
Article - Journal
© 2016 John Wiley & Sons Inc., All rights reserved.
01 Oct 2016