Fabrication, Characterization, and in Vitro Evaluation of Silver-Containing Arabinoxylan Foams as Antimicrobial Wound Dressing

Abstract

Arabinoxylan ferulate (AXF) foams were fabricated via enzymatic peroxidase/hydrogen peroxide crosslinking reaction followed by freeze-drying and studied as a potential wound dressing material. The AXF foam's rheological, morphological, porous, and swelling properties were examined. AXF foams were found to be a viscoelastic material that proved to be highly porous and water absorbent. AXF foams possessed low endotoxin levels and were cytocompatible with fibroblasts. Silver was successfully integrated into AXF foams and slowly released over 48 h. AXF foams impregnated with silver demonstrated efficacy inhibiting bacterial growth according to a modified Kirby-Bauer disk diffusion susceptibility test. Overall, AXF foams possess appropriate material properties and the silver-loaded AXF foams showed antimicrobial activity necessary to be a candidate material in wound dressing development.

Department(s)

Chemical and Biochemical Engineering

Comments

This work was supported, in part, by the National Science Foundation (CAREER award CBET0954957) and National Institutes of Health (R01EY024072).

Keywords and Phrases

arabinoxylan; Kirby-Bauer disk diffusion susceptibility test; polysaccharide; silver dressing; wound healing

International Standard Serial Number (ISSN)

1549-3296; 1552-4965

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2016 John Wiley & Sons Inc., All rights reserved.

Publication Date

01 Oct 2016

PubMed ID

27199211

Link to Full Text

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