Electrospun Gelatin-arabinoxylan Ferulate Composite Fibers for Diabetic Chronic Wound Dressing Application
Abstract
Blends of arabinoxylan ferulate (AXF) and gelatin (GEL) at 1:1, 2:1 and 4:1 mass ratios were electrospun into composite fibrous mats as a wound-healing drug delivery platform. The composite fibers were characterized in terms of morphology, tensile properties, pore size, porosity and molecular composition. The composite fibers showed excellent cytocompatibility. Silver was impregnated into GEL-AXF nanofibers, and it was slowly released, resulting in bacterial growth inhibition as confirmed by the Kirby—Bauer disk-diffusion assay. This work establishes an electrospun arabinoxylan fibrous material platform with the potential to treat chronic diabetic wounds.
Recommended Citation
D. C. Aduba et al., "Electrospun Gelatin-arabinoxylan Ferulate Composite Fibers for Diabetic Chronic Wound Dressing Application," International Journal of Polymeric Materials and Polymeric Biomaterials, vol. 68, no. 11, pp. 660 - 668, Taylor & Francis, Jul 2019.
The definitive version is available at https://doi.org/10.1080/00914037.2018.1482466
Department(s)
Chemical and Biochemical Engineering
Research Center/Lab(s)
Center for Research in Energy and Environment (CREE)
Keywords and Phrases
Arabinoxylan; chronic wound; diabetes; electrospinning; gelatin; nanofiber; wound dressing
International Standard Serial Number (ISSN)
0091-4037; 1563-535X
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2019 Taylor & Francis, All rights reserved.
Publication Date
24 Jul 2019
Comments
This work was supported, in part, by the National Science Foundation (CAREER award CBET0954957).