Dendrimers for Pharmaceutical and Biomedical Applications

Author

Hu Yang, Missouri University of Science and TechnologyFollow
Weiyuan John Kao

Abstract

Dendrimers are a unique class of synthetic macromolecules having a highly branched, three-dimensional, nanoscale architecture with very low polydispersity and high functionality. Structural advantages allow dendrimers to play an important role in the fields of nanotechnology, pharmaceutical and medicinal chemistry. This review discusses several aspects of dendrimers, including preparation, dendrimer-drug coupling chemistry, structural models of dendrimer-based drug delivery systems, and physicochemical and toxicological properties.

Recommended Citation

H. Yang and W. J. Kao, "Dendrimers for Pharmaceutical and Biomedical Applications," Journal of Biomaterials Science, Polymer Edition, vol. 17, no. 1, pp. 3 - 19, VSP, Jan 2006.

The definitive version is available at https://doi.org/10.1163/156856206774879171

Department(s)

Chemical and Biochemical Engineering

Comments

This work was supported by an NIH Grant HL-077825.

Keywords and Phrases

Biomaterials; Dendrimer; Drug delivery; Nanomedicine; Polyamidoamine (PAMAM) dendrimer

International Standard Serial Number (ISSN)

0920-5063; 1568-5624

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2006 VSP, All rights reserved.

Publication Date

01 Jan 2006

PubMed ID

16411595