Branched Polyrotaxane Hydrogels Consisting of Alpha-Cyclodextrin and Low-Molecular-Weight Four-Arm Polyethylene Glycol and the Utility of their Thixotropic Property for Controlled Drug Release

Abstract

In this work, we developed a new class of branched polyrotaxane hydrogel made of 4-arm polyethylene glycol (4-PEG) and α-cyclodextrin (α-CD) using supramolecular host-guest interactions as a cross-linking strategy. Because of the dynamic nature of the non-covalent host-guest cross-linking, the resulting supramolecular α-CD/4-PEG hydrogels show thixotropic behavior and undergo a reversible gel-sol transition in response to shear stress change. We loaded the antiglaucoma drug brimonidine into the α-CD/4-PEG gel and found the drug release kinetics was controlled by shear stress. This thixotropic shear thinning property makes the supramolecular hydrogels highly attractive in drug delivery applications and suitable for preparation of injectable drug formulations.

Department(s)

Chemical and Biochemical Engineering

Comments

This work was supported, in part, by the National Institutes of Health ( R01EY024072 ).

Keywords and Phrases

Branched PEG; Glaucoma; Host-guest interaction; Supramolecular; Thixotropic

International Standard Serial Number (ISSN)

0927-7765

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2018 Elsevier B.V., All rights reserved.

Publication Date

01 May 2018

PubMed ID

29476924

Link to Full Text

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