Abstract
To improve delivery efficiency of anastrozole, we applied dendrimer-based stealth nanoparticles to encapsulate anastrozole to formulate stealth anastrozole nanoparticles. This work demonstrated that stealth nanoparticles composed of a PAMAM dendrimers core and a PEG layer could encapsulate anastrozole, hence causing improved water solubility of anastrozole. Anastrozole encapsulation depended on concentration of stealth nanoparticles and generation of dendrimer. The extended release of anastrozole was achieved. We envisioned that this highly structurally adaptable stealth nanoparticle could be further biofunctionalized to construct a targeted therapeutic delivery system for breast cancer treatment.
Recommended Citation
K. Sarkar and H. Yang, "Encapsulation and Extended Release of Anti-Cancer Anastrozole by Stealth Nanoparticles," Drug Delivery, vol. 15, no. 5, pp. 343 - 346, Taylor & Francis, Jun 2008.
The definitive version is available at https://doi.org/10.1080/10717540802035343
Department(s)
Chemical and Biochemical Engineering
Keywords and Phrases
Anastrozole; Controlled release; Drug delivery; Nanomedicine; Nanoparticle; PAMAM dendrimer; PEG
International Standard Serial Number (ISSN)
1071-7544; 1521-0464
Document Type
Article - Journal
Document Version
Final Version
File Type
text
Language(s)
English
Rights
© 2008 Informa Healthcare USA, Inc., All rights reserved.
Publication Date
01 Jun 2008
PubMed ID
18763165
Comments
This research was supported in part by the A.D. Williams Foundation, the Jeffress Memorial Trust, and a new faculty startup fund from the School of Engineering of Virginia Commonwealth University.