Reactive Flash Nanoprecipitation: Expanding The Landscape Of Nanoparticle Fabrication For Biomedical Applications

Abstract

Scaling up nanoparticle production remains a major challenge that limits the translation of nanotechnology. Flash nanoprecipitation (FNP), first introduced by Prud'homme in 2003, offers a promising approach to bridging laboratory-scale synthesis and industrial manufacturing. Building on his pioneering work, FNP has been applied not only to fabricate nanoparticles encapsulating hydrophobic drugs but also to generate particles with increasingly complex architectures. In this perspective, recent developments in the field are highlighted, and an emerging direction is proposed: reactive FNP (rFNP). rFNP involves in-situ crosslinking and possibly other chemical reactions in the flash nanoprecipitation process. Selected chemical reactions, such as click chemistry and precipitation reactions, can be utilized in rFNP to create nanoparticles with enhanced chemical stability, improved physical properties, and broader functional capabilities. While this perspective is centered on new opportunities for applying rFNP-based strategies in biomedical and pharmaceutical applications, rFNP also has broader applications across a wide range of other fields.

Department(s)

Chemical and Biochemical Engineering

Comments

National Institutes of Health, Grant R01HL140684

Keywords and Phrases

click chemistry; confined impinging jet mixer; drug delivery; gene delivery; multi-inlet vortex mixer; Reactive flash nanoprecipitation

International Standard Serial Number (ISSN)

1563-535X; 0091-4037

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2026 Taylor and Francis Group; Taylor and Francis, All rights reserved.

Publication Date

01 Jan 2026

Link to Full Text

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