Abstract
Regional delivery of chimeric antigen receptor (CAR) T cells in glioblastoma represents a rational therapeutic approach as an alternative to intravenous administration to avoid the blood-brain barrier impediment. Here, we developed a fibrin gel that accommodates CAR-T cell loading and promotes their gradual release. Using a model of subtotal glioblastoma resection, we demonstrated that the fibrin-based gel delivery of CAR-T cells within the surgical cavity enables superior antitumor activity compared to CAR-T cells directly inoculated into the tumor resection cavity.
Recommended Citation
E. A. Ogunnaike and A. Valdivia and M. Yazdimamaghani and E. Leon and S. Nandi and H. Hudson and H. Du and S. Khagi and Z. Gu and B. Savoldo and F. S. Ligler and S. Hingtgen and G. Dotti, "Fibrin Gel Enhances The Antitumor Effects Of Chimeric Antigen Receptor T Cells In Glioblastoma," Science Advances, vol. 7, no. 41, article no. eabg5841, American Association for the Advancement of Science, Oct 2021.
The definitive version is available at https://doi.org/10.1126/sciadv.abg5841
Department(s)
Chemical and Biochemical Engineering
Publication Status
Open Access
International Standard Serial Number (ISSN)
2375-2548
Document Type
Article - Journal
Document Version
Final Version
File Type
text
Language(s)
English
Rights
© 2025 The Authors, All rights reserved.
Creative Commons Licensing
This work is licensed under a Creative Commons Attribution 4.0 License.
Publication Date
01 Oct 2021
PubMed ID
34613775
Comments
National Cancer Institute, Grant R25NS094093