Abstract
Magnesium (Mg) is a promising candidate to be used in medical products especially as bone tissue engineering scaffolds. The main challenge for using Mg in biomedical applications is its high degradation rate in the body. For this reason, in this study, a multilayer polymeric layer composed of polycaprolactone (PCL) and gelatin (Gel) reinforced with bioactive glass (BaG) particles has been applied on the surface of Mg scaffolds. The materials characteristics of uncoated Mg scaffold, Mg scaffold coated only with PCL-BaG and Mg scaffold coated with PCL-BaG and Gel-BaG have been analyzed and compared in detail. Scanning electron microscope (SEM) equipped with energy dispersive spectroscopy (EDS), and Fourier transform infrared spectroscopy (FTIR) were utilized for microstructural studies. In vitro bioactivity and biodegradation evaluations were carried out by submerging the scaffolds in simulated body fluid (SBF) at pre-determined time points. The results demonstrated that Mg scaffold coated with PCL-BaG and Gel-BaG exhibited significant improvement in biodegradability.
Recommended Citation
M. Yazdimamaghani et al., "Significant Degradability Enhancement In Multilayer Coating Of Polycaprolactone-bioactive Glass/gelatin-bioactive Glass On Magnesium Scaffold For Tissue Engineering Applications," Applied Surface Science, vol. 338, pp. 137 - 145, Elsevier, May 2015.
The definitive version is available at https://doi.org/10.1016/j.apsusc.2015.02.120
Department(s)
Chemical and Biochemical Engineering
Publication Status
Full Text Access
Keywords and Phrases
Biodegradation; Bone tissue engineering; Coating; Mg scaffold; Surface modification
International Standard Serial Number (ISSN)
0169-4332
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2025 Elsevier, All rights reserved.
Publication Date
30 May 2015
Comments
Air Force Office of Scientific Research, Grant 0933763