Vascularization

Abstract

Investigating the innate organs and tissues reveals existence of abundant capillaries supporting the tissue with providing oxygen and nutrients, and withdrawing waste materials. Extensive studies in the tissue regeneration field have disclosed the critical importance of vascular network in the structure of laboratory-based scaffolds. To a great extent, the main reason for the lack of a successful synthetic three-dimensional bone tissue-engineering scaffolds is the inability for functional vascularization induction. State-of-the-art and novel approaches towards vascularization would yield promising results in different fields like tissue regeneration, drug discovery, and medical research. Hence, strategies resulting in augmentation of vascular network formation such as utilizing growth factors, cytokines, cell delivery, vascular inductive scaffold, and microsurgery strategies have attracted major attention in the tissue-engineering research community. Herein, we review the rationale for vascularization of engineered tissues, current state-of-the-art strategies to increment vascularization, and key challenges toward successful formation of vascular network within engineered constructs for bone tissue engineering.

Department(s)

Chemical and Biochemical Engineering

Keywords and Phrases

Bone scaffold; Bone tissue engineering; Vascular network; Vascularization

International Standard Book Number (ISBN)

978-008100961-1;978-008100967-3

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2025 Woodhead Publishing, All rights reserved.

Publication Date

01 Aug 2017

Link to Full Text

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