Abstract
Poor water solubility, off-target toxicity, and small therapeutic window are among major obstacles for the development of drug products. Redox-responsive drug delivery nanoplatforms not only overcome the delivery and pharmacokinetic pitfalls observed in conventional drug delivery but also leverage the site-specific delivery properties. Cleavable diselenide and disulfide bonds in the presence of elevated reactive oxygen species (ROS) and glutathione concentration are among widely used stimuli-responsive bonds to design nanocarriers. This review covers a wide range of redox-responsive chemical structures and their properties for designing nanoparticles aiming controlled loading, delivery, and release of hydrophobic anticancer drugs at tumor site.
Recommended Citation
S. Mollazadeh et al., "Recent Advances In The Redox-responsive Drug Delivery Nanoplatforms: A Chemical Structure And Physical Property Perspective," Materials Science and Engineering C, vol. 118, article no. 111536, Elsevier BV, Jan 2021.
The definitive version is available at https://doi.org/10.1016/j.msec.2020.111536
Department(s)
Chemical and Biochemical Engineering
Publication Status
Complimentary Access
Keywords and Phrases
Cleavable linkers; Drug delivery; Nanomedicine; Nanoparticle; Redox-responsive
International Standard Serial Number (ISSN)
1873-0191; 0928-4931
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2025 Elsevier BV, All rights reserved.
Publication Date
01 Jan 2021
PubMed ID
33255089
