Abstract
Over the past decade, boldine, a naturally occurring alkaloid found in several plant species including the Chilean Boldo tree, has garnered attention for its efficacy in rodent models of human disease. Some of the properties that have been attributed to boldine include antioxidant activities, neuroprotective and analgesic actions, hepatoprotective effects, anti-inflammatory actions, cardioprotective effects and anticancer potential. Compelling data now indicates that boldine blocks connexin (Cx) hemichannels (HCs) and that many if not all of its effects in rodent models of injury and disease are due to CxHC blockade. Here we provide an overview of boldine's pharmacological properties, including its efficacy in rodent models of common human injuries and diseases, and of its absorption, distribution, pharmacokinetics, and metabolism.
Recommended Citation
J. C. Sáez and J. C. Burrell and C. M. Cahill and D. K. Cullen and L. A. Devi and R. J. Gilbert and Z. A. Graham and V. J. Gurvich and L. A. Havton and R. Iyengar and R. Khanna and E. F. Palermo and M. Siddiq and C. A. Toro and W. Vasquez and W. Zhao and C. P. Cardozo, "Pharmacology of Boldine: Summary of the Field and Update on Recent Advances," Frontiers in Pharmacology, vol. 15, article no. 1427147, Frontiers Media, Jan 2024.
The definitive version is available at https://doi.org/10.3389/fphar.2024.1427147
Department(s)
Chemical and Biochemical Engineering
Publication Status
Open Access
Keywords and Phrases
boldine; connexin (Cx); hemichannels; pharmacology; phramacokinetics
International Standard Serial Number (ISSN)
1663-9812
Document Type
Article - Journal
Document Version
Final Version
File Type
text
Language(s)
English
Rights
© 2025 The Authors, All rights reserved.
Creative Commons Licensing
This work is licensed under a Creative Commons Attribution 4.0 License.
Publication Date
01 Jan 2024
