Abstract
Composites combining superparamagnetic iron oxide nanoparticles (SPIONs) and polymers are largely present in modern (bio)materials. However, although SPIONs embedded in polymer matrices are classically reported, the mechanical and degradation properties of the polymer scaffold are impacted by the SPIONs. Therefore, the controlled anchoring of SPIONs onto polymer surfaces is still a major challenge. Herein, we propose an efficient strategy for the direct and uniform anchoring of SPIONs on the surface of functionalized-polylactide (PLA) nanofibers via a simple free ligand exchange procedure to design PLA@SPIONs core@shell nanocomposites. The resulting PLA@SPIONs hybrid biomaterials are characterized by electron microscopy (scanning electron microscopy and transmission electron microscopy) and energy-dispersive X-ray spectroscopy analysis to probe the morphology and detect elements present at the organic-inorganic interface, respectively. A monolayer of SPIONs with a complete and homogeneous coverage is observed on the surface of PLA nanofibers. Magnetization experiments show that magnetic properties of the nanoparticles are well preserved after their grafting on the PLA fibers and that the size of the nanoparticles does not change. The absence of cytotoxicity, combined with a high sensitivity of detection in magnetic resonance imaging both in vitro and in vivo, makes these hybrid nanocomposites attractive for the development of magnetic biomaterials for biomedical applications.
Recommended Citation
H. Awada and A. Al Samad and D. Laurencin and R. Gilbert and X. Dumail and A. El Jundi and A. Bethry and R. Pomrenke and C. Johnson and L. Lemaire and F. Franconi and G. Félix and J. Larionova and Y. Guari and B. Nottelet, "Controlled Anchoring of Iron Oxide Nanoparticles on Polymeric Nanofibers: Easy Access to Core@Shell Organic-Inorganic Nanocomposites for Magneto-Scaffolds," ACS Applied Materials and Interfaces, vol. 11, no. 9, pp. 9519 - 9529, American Chemical Society, Mar 2019.
The definitive version is available at https://doi.org/10.1021/acsami.8b19099
Department(s)
Chemical and Biochemical Engineering
Keywords and Phrases
core@shell nanocomposite; hybrid biomaterial; iron oxide nanoparticles; MRI and magnetic properties; poly(lactide) nanofibers
International Standard Serial Number (ISSN)
1944-8252; 1944-8244
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2025 American Chemical Society, All rights reserved.
Publication Date
06 Mar 2019
PubMed ID
30729776
Comments
Rensselaer Polytechnic Institute, Grant ANR-11-INBS-0006