Abstract
Electro spun poly-l-lactic acid (PLLA) fiber scaffolds are used to direct axonal extension in neural engineering models. We aimed to improve the efficacy of these fibers in promoting neurite outgrowth by altering surface topography and reducing fiber elastic modulus through the incorporation of a compatibilized blend, poly-l-lactic acid-poly(pentadecalactone) (PLLA-PPDL) into the solution prior to electrospinning. PLLA+PLLA-PPDL fibers had a larger diameter, increased surface nano topography, and lower glass transition temperature than PLLA fibers but had similar mechanical properties. Increases in neurite outgrowth on PLLA+PLLA-PPDL fibers were observed, potentially due to the significantly increased diameter and surface coverage with nano topography. Ultimately, these results suggest that greater electro spun fiber diameter and surface topography may contribute to increases in neurite outgrowth.
Recommended Citation
A. M. Ziemba and K. P. Lane and I. M. San Segundo and A. R. D'Amato and A. K. Mason and R. J. Sexton and H. Casajus and R. A. Gross and D. T. Corr and R. J. Gilbert, "Poly- L -lactic Acid- Co-poly(pentadecalactone) Electrospun Fibers Result in Greater Neurite Outgrowth of Chick Dorsal Root Ganglia in Vitro Compared to Poly- L -lactic Acid Fibers," ACS Biomaterials Science and Engineering, vol. 4, no. 5, pp. 1491 - 1497, American Chemical Society, May 2018.
The definitive version is available at https://doi.org/10.1021/acsbiomaterials.8b00013
Department(s)
Chemical and Biochemical Engineering
Keywords and Phrases
dorsal root ganglia; electrospun fibers; mechanical property; neural engineering; neurite outgrowth; surface topography
International Standard Serial Number (ISSN)
2373-9878
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2025 American Chemical Society, All rights reserved.
Publication Date
14 May 2018
PubMed ID
33445306
Comments
National Science Foundation, Grant 1150125