Abstract
Peritoneal macrophages (PMACs) and spinal cord astrocytes were exposed to varying concentrations of soluble sophorolipid butyl ester diacetate (SLBEDA) in vitro. Macrophages and astrocytes demonstrated no decrease in viability in response to SLBEDA. Studying pro- and anti-inflammatory genes, PMACs did not show a shift toward a pro-inflammatory phenotype. However, at higher concentrations (3 and 30 μM), astrocytes showed an increase in their expression of glial acidic fibrillary protein. This novel category of compounds poses low risk to PMAC and astrocyte viability; however, the effect on PMAC polarization and astrocyte reactivity requires more elucidation.
Recommended Citation
A. M. Ziemba et al., "Sophorolipid Butyl Ester Diacetate Does Not Affect Macrophage Polarization But Enhances Astrocytic Glial Fibrillary Acidic Protein Expression at Micromolar Concentrations in Vitro," ACS Chemical Neuroscience, vol. 8, no. 4, pp. 752 - 758, American Chemical Society, Apr 2017.
The definitive version is available at https://doi.org/10.1021/acschemneuro.6b00451
Department(s)
Chemical and Biochemical Engineering
Keywords and Phrases
astrocyte; Macrophage; sophorolipid; spinal cord injury
International Standard Serial Number (ISSN)
1948-7193
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2025 American Chemical Society, All rights reserved.
Publication Date
19 Apr 2017
PubMed ID
28140557
Comments
National Science Foundation, Grant 1508422