Abstract
The hydrophobicity of electro spun poly-l-lactic acid (PLLA) fibers hinders their integration with surrounding tissue for a variety of applications. In this study, we increased PLLA fiber hydrophilicity by incorporating the natural surfactant, lactonic sophorolipid (LSL). PLLA+LSL fibers had similar fiber morphology but significantly greater surface wettability, which suggested LSL accumulation on the fiber surface. Differential scanning calorimetry results also suggested that LSL was phase separated from PLLA. Despite the altered surface wettability of these fibers, there was no change in fibroblast adhesion. Future studies may explore the use of this natural surfactant to deliver bioactive factors to enhance fibroblast adhesion.
Recommended Citation
A. M. Ziemba et al., "Lactonic Sophorolipid Increases Surface Wettability of Poly- L -lactic Acid Electrospun Fibers," ACS Applied Bio Materials, vol. 2, no. 8, pp. 3153 - 3158, American Chemical Society, Aug 2019.
The definitive version is available at https://doi.org/10.1021/acsabm.9b00268
Department(s)
Chemical and Biochemical Engineering
Keywords and Phrases
electrospun fiber; fibroblast; lactonic sophorolipid; poly- l -lactic acid; surface wettability
International Standard Serial Number (ISSN)
2576-6422
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2025 American Chemical Society, All rights reserved.
Publication Date
19 Aug 2019
PubMed ID
35030759
Comments
National Science Foundation, Grant 1150125