Abstract
We describe the patterning of neuronal cultures by a laser-based printing system. Embryonic chick cortical neurons were transferred into predetermined array positions with micron accuracy, enabling detailed study of neuronal migration, aggregation, and neurite outgrowth regulated by cell-cell interactions on a homogeneous surface. Images of cells were analyzed up to 14 days. Results demonstrated that increasing the spacing between neighboring groups of cells causes intra-group cells to preferentially migrate towards each other and aggregate towards the center of the printed 'spot'. In addition, increasing the printed 'spot' size encouraged migration towards neighboring groups of cells. © 2012 IEEE.
Recommended Citation
T. B. Phamduy et al., "Examination of the Migratory Potential of Patterned Cortical Neurons using Laser Direct-write," 2012 38th Annual Northeast Bioengineering Conference Nebec 2012, pp. 291 - 292, article no. 6207079, Institute of Electrical and Electronics Engineers, Jun 2012.
The definitive version is available at https://doi.org/10.1109/NEBC.2012.6207079
Department(s)
Chemical and Biochemical Engineering
International Standard Book Number (ISBN)
978-146731141-0
Document Type
Article - Conference proceedings
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2025 Institute of Electrical and Electronics Engineers, All rights reserved.
Publication Date
29 Jun 2012
