Abstract
Tissue engineering scaffolds are often designed without appropriate consideration for the translational potential of the material. Solid scaffolds implanted into central nervous system (CNS) tissue to promote regeneration may require tissue resection to accommodate implantation. Or alternatively, the solid scaffold may be cut or shaped to better fit an irregular injury geometry, but some features of the augmented scaffold may fail to integrate with surrounding tissue reducing regeneration potential. To create a biomaterial able to completely fill the irregular geometry of CNS injury and yet still provide sufficient cell migratory cues, an injectable, hybrid scaffold was created to present the physical architecture of electro spun fibers in an agarose/methylcellulose hydrogel. When injected into the rat striatum, infiltrating macrophages/microglia and resident astrocytes are able to locate the fibers and utilize their cues for migration into the hybrid matrix. Thus, hydrogels containing electro spun fibers may be an appropriate platform to encourage regeneration of the injured brain.
Recommended Citation
C. J. Rivet et al., "Cell Infiltration into a 3D Electrospun Fiber and Hydrogel Hybrid Scaffold Implanted in the Brain," Biomatter, vol. 5, p. e1005527, Taylor and Francis Group, Taylor and Francis, Jan 2015.
The definitive version is available at https://doi.org/10.1080/21592535.2015.1005527
Department(s)
Chemical and Biochemical Engineering
Keywords and Phrases
brain; electrospun fibers; hydrogel; neuroengineering
International Standard Serial Number (ISSN)
2159-2535
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2025 Taylor and Francis Group, Taylor and Francis, All rights reserved.
Publication Date
01 Jan 2015
PubMed ID
25996265
Comments
Australian Research Council, Grant DP0985433