Abstract
In an attempt to increase the rate of neurite extension from E9 chick embryo dorsal root ganglion (DRG) on electro spun fiber scaffolds we experimented with two drugs that have been used previously to affect neuronal growth. Blebbistatin and paclitaxel were added to DRG cultured on electro spun fibers in an attempt to increase the rate of neurite extension along fibrous scaffolds. Blebbistatin increased the length of neurites extending from the DRG explant in comparison to the drug-free control group. In contrast, paclitaxel completely eliminated all neurite extension from the DRG explant when compared to the control. A third treatment group which combined both drugs also resulted in no neurite extension from the DRG explant as was found in all paclitaxel containing treatment groups.
Recommended Citation
A. R. D'Amato et al., "Analysis of Neurite Outgrowth on Electrospun Fiber Scaffolds in the Presence of Blebbistatin and Paclitaxel," 2015 41st Annual Northeast Biomedical Engineering Conference Nebec 2015, article no. 7117141, Institute of Electrical and Electronics Engineers, Jun 2015.
The definitive version is available at https://doi.org/10.1109/NEBEC.2015.7117141
Department(s)
Chemical and Biochemical Engineering
Keywords and Phrases
Biomaterials; Blebbistatin; DRG; Electrospun fibers; Neurite; Paclitaxel
International Standard Book Number (ISBN)
978-147998360-5
Document Type
Article - Conference proceedings
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2025 Institute of Electrical and Electronics Engineers, All rights reserved.
Publication Date
02 Jun 2015
