Abstract
Nerve growth factor releasing composite nanoparticles (NGF-cNPs) were developed to direct the extension of neurite outgrowth from dorsal root ganglia (DRG). Iron oxide magnetic nanoparticles were incorporated into poly-l-lactic acid (PLLA) nanoparticles in order to position the NGF-cNPs in a culture dish. Neurites growing from DRG extended toward the NGF released from the NGF-cNPs. DRG were then cultured on aligned PLLA microfibers in the presence of NGF-cNPs, and these biomaterials combined to align DRG neurite extension along one axis and preferentially toward the NGF-cNPs. This combinatorial biomaterial approach shows promise as a strategy to direct the extension of regenerating neurites.
Recommended Citation
J. M. Zuidema et al., "Magnetic NGF-Releasing PLLA/Iron Oxide Nanoparticles Direct Extending Neurites and Preferentially Guide Neurites Along Aligned Electrospun Microfibers," ACS Chemical Neuroscience, vol. 6, no. 11, pp. 1781 - 1788, American Chemical Society, Aug 2015.
The definitive version is available at https://doi.org/10.1021/acschemneuro.5b00189
Department(s)
Chemical and Biochemical Engineering
Keywords and Phrases
electrospun fiber; magnetic nanoparticle; nerve growth factor; neurite extension; Poly- l -lactic acid
International Standard Serial Number (ISSN)
1948-7193
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2025 American Chemical Society, All rights reserved.
Publication Date
31 Aug 2015
PubMed ID
26322376
Comments
National Stroke Foundation, Grant 1150125