Biomaterial Design Considerations for Repairing the Injured Spinal Cord

Abstract

With increasing regularity, biomaterials are being designed with the goal of promoting repair of the injured spinal cord. Most often, the efficacy of novel biomaterials is tested using in vitro models; however, their true potential will be realized only after they are applied and evaluated in standardized in vivo spinal cord injury (SCI) models. The purpose of this review is to (1) provide a primer on SCI research including an overview of common pathogenic mechanisms that may respond to biomaterials and the in vivo models and outcomes assessment tools used to evaluate therapeutic efficacy; (2) review the types of biomaterials that have been tested in these models; (3) discuss which biomaterials might be applied to these models in the future; and (4) recommend future engineering strategies to create better in vivo models and assessment tools. © 2011 by Begell House, Inc.

Department(s)

Chemical and Biochemical Engineering

Keywords and Phrases

Biomaterials; Spinal cord injury; Spinal cord injury models

International Standard Serial Number (ISSN)

0278-940X

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2025 Begell House, All rights reserved.

Publication Date

01 Jan 2011

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