Advances in the Use of Electrospun Fibers for the Central Nervous System
Abstract
Electrospun fibers are commonly used for tissue engineering purposes. The topography of nano- and microfibrous scaffolds enables cells to attach and migrate by providing a network that is similar to the extracellular matrix (ECM). The use of aligned electrospun fiber scaffolds is particularly relevant in spinal cord injury (SCI), where directed uniaxial axonal extension is required for regeneration. In this chapter, we review SCI pathophysiology and discuss the applications of electrospun fibers for SCI. We highlight state-of-the-art fibers for SCI and their use in cell and animal SCI models. While experimental approaches utilizing electrospun fibers in the central nervous system (CNS) focus on SCI, we also explore the potential use of electrospun fibers within traumatic brain injury (TBI).
Recommended Citation
A. R. D'Amato et al., "Advances in the Use of Electrospun Fibers for the Central Nervous System," Electrofluidodynamic Technologies Efdts for Biomaterials and Medical Devices Principles and Advances, pp. 377 - 398, Elsevier, Jan 2018.
The definitive version is available at https://doi.org/10.1016/B978-0-08-101745-6.00018-9
Department(s)
Chemical and Biochemical Engineering
Keywords and Phrases
Biomaterials; Central nervous system; Spinal cord injury; Traumatic brain injury
International Standard Book Number (ISBN)
978-008101745-6;978-008101746-3
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2025 Elsevier, All rights reserved.
Publication Date
20 Jan 2018
