Abstract
Poly-L-lactic acid (PLLA) is an extensively studied synthetic polymer that has demonstrated utility as a scaffolding material. A common technique for the fabrication of PLLA scaffolds is electrospinning. The purpose of the present material study was to assess whether an electrospinning process could produce consistent and uniform PLLA scaffold densities. An 8% PLLA solution was made using a 1:1 chloroform: dichloromethane solution and was then run through an electrospinning apparatus. Samples were spun onto 4% PLLA films for 2- or 20-min. Scanning electron microscopy (SEM) was used for imaging the scaffolds. A nine-measurement data set was used for the assessment of each scaffold density. Image analysis demonstrated that the electrospinning time and density of the scaffolds were directly related and produced fiber densities within a time dependent range of variation across the entire scaffold. Development of this process may improve current protocols for polymer fiber scaffold fabrication and produce superior scaffolds for both in vitro and in vivo applications. © 2011 IEEE.
Recommended Citation
N. W. Zaccor et al., "Fabrication and Analysis of Variable Density Poly-(L)-lactic Acid Fiber Scaffolds," 2011 IEEE 37th Annual Northeast Bioengineering Conference Nebec 2011, article no. 5778600, Institute of Electrical and Electronics Engineers, Jun 2011.
The definitive version is available at https://doi.org/10.1109/NEBC.2011.5778600
Department(s)
Chemical and Biochemical Engineering
International Standard Book Number (ISBN)
978-161284827-3
Document Type
Article - Conference proceedings
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2025 Institute of Electrical and Electronics Engineers, All rights reserved.
Publication Date
16 Jun 2011
