Nanoparticle Technologies in the Spinal Cord
Abstract
Nanoparticles are increasingly being studied within experimental models of spinal cord injury (SCI). They are used to image cells and tissue, move cells to specific regions of the spinal cord, and deliver therapeutic agents locally. The focus of this article is to provide a brief overview of the different types of nanoparticles being studied for spinal cord applications and present data showing the capability of nanoparticles to deliver the chondroitinase ABC (chABC) enzyme locally following acute SCI in rats. Nanoparticles releasing chABC helped promote axonal regeneration following injury, and the nanoparticles also protected the enzyme from rapid degradation. In summary, nanoparticles are viable materials for diagnostic or therapeutic applications within experimental models of SCI and have potential for future clinical use.
Recommended Citation
J. M. Zuidema et al., "Nanoparticle Technologies in the Spinal Cord," Cells Tissues Organs, vol. 202, no. 1 thru 2, pp. 102 - 115, Karger Publishers, Oct 2016.
The definitive version is available at https://doi.org/10.1159/000446647
Department(s)
Chemical and Biochemical Engineering
Keywords and Phrases
Chondroitinase ABC; Drug delivery; Nanoparticle; Poly-L-lactic acid; Spinal cord injury
International Standard Serial Number (ISSN)
1422-6421; 1422-6405
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2025 Karger Publishers, All rights reserved.
Publication Date
01 Oct 2016
PubMed ID
27701150
Comments
National Institute of Neurological Disorders and Stroke, Grant R01NS092754