Abstract
Nervous system damage caused by physical trauma or degenerative diseases can result in loss of sensory and motor function for patients. Biomaterial interventions have shown promise in animal studies, providing contact guidance for extending neurites or sustained release of various drugs and growth factors; however, these approaches often target only one aspect of the regeneration process. More recent studies investigate hybrid approaches, creating complex materials that can reduce inflammation or provide neuroprotection in addition to stimulating growth and regeneration. Magnetic materials have shown promise in this field, as they can be manipulated non-invasively, are easily functionalized, and can be used to mechanically stimulate cells. By combining different types of biomaterials (hydrogels, nanoparticles, electro spun fibers) and incorporating magnetic elements, magnetic materials can provide multiple physical and chemical cues to promote regeneration. This review, for the first time, will provide an overview of design strategies for promoting regeneration after neural injury with magnetic biomaterials.
Recommended Citation
J. L. Funnell et al., "Magnetic Composite Biomaterials for Neural Regeneration," Frontiers in Bioengineering and Biotechnology, vol. 7, article no. 179, Frontiers Media, Jan 2019.
The definitive version is available at https://doi.org/10.3389/fbioe.2019.00179
Department(s)
Chemical and Biochemical Engineering
Publication Status
Open Access
Keywords and Phrases
Biomaterials; Iron oxide nanoparticles; Magnetic nanoparticles; Nervous system injury; Neural regeneration
International Standard Serial Number (ISSN)
2296-4185
Document Type
Article - Journal
Document Version
Final Version
File Type
text
Language(s)
English
Rights
© 2025 The Authors, All rights reserved.
Creative Commons Licensing
This work is licensed under a Creative Commons Attribution 4.0 License.
Publication Date
01 Jan 2019
Comments
National Institutes of Health, Grant R01NS092754