Biomaterial Strategies for Creating in Vitro Astrocyte Cultures Resembling in Vivo Astrocyte Morphologies and Phenotypes
Abstract
Astrocytes are dynamic cells residing in the central nervous system exhibiting many diverse functions. Astrocytes quickly change and present unique phenotypes in response to injury or disease. Here, we briefly summarize recent information regarding astrocyte morphology and function and provide brief insight into their phenotypic changes after injury or disease. We also present the use of in vitro astrocyte cultures and present recent advances in biomaterial development that enable better recapitulation of their in vivo behavior and morphology.
Recommended Citation
M. K. Gottipati et al., "Biomaterial Strategies for Creating in Vitro Astrocyte Cultures Resembling in Vivo Astrocyte Morphologies and Phenotypes," Current Opinion in Biomedical Engineering, vol. 14, pp. 67 - 74, Elsevier, Jun 2020.
The definitive version is available at https://doi.org/10.1016/j.cobme.2020.06.004
Department(s)
Chemical and Biochemical Engineering
Keywords and Phrases
3D cultures; Astrocytes; Biomaterials; Reactive astrogliosis
International Standard Serial Number (ISSN)
2468-4511
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2025 Elsevier, All rights reserved.
Publication Date
01 Jun 2020
Comments
National Institutes of Health, Grant C32245GG