Abstract
Electro spun an fibers hydrogels are two focal points of research within the biomaterial's community. The electrospinning process allows for fabrication of nanoscale, aligned topography and has been shown to direct cellular migration and outgrowth. Hydrogels exhibit benefits over traditional, rigid scaffolds in that they are injectable and can be tailored to mimic the mechanical properties of the surrounding tissue. Although both electro spun fibers and hydrogels display favorable characteristics for biomedical applications in vitro, there in vivo benefits are limited due to inherent deficiencies Therefore, to advance the field of biomaterials research, a composite material containing electro spun fibers dispersed throughout a hydrogel matrix was created. Preliminary investigations into characterization of this material configuration by rheological assessment show that the addition of fibers alters the elastic modulus of material. Furthermore, incorporation of the fibers within the hydrogel is capable of directing neurite outgrowth. The benefits of such a configuration are widespread throughout the tissue engineering field and may provide new strategies to overcome current limitations. © 2011 IEEE.
Recommended Citation
C. J. Rivet and R. J. Gilbert, "Fabrication and Characterization of a Hydrogel Containing Electrospun Fibers," 2011 IEEE 37th Annual Northeast Bioengineering Conference Nebec 2011, article no. 5778701, Institute of Electrical and Electronics Engineers, Jun 2011.
The definitive version is available at https://doi.org/10.1109/NEBC.2011.5778701
Department(s)
Chemical and Biochemical Engineering
International Standard Book Number (ISBN)
978-161284827-3
Document Type
Article - Conference proceedings
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2025 Institute of Electrical and Electronics Engineers, All rights reserved.
Publication Date
16 Jun 2011
