Abstract
A series of glasses (0.48SiO2 − [0.40-x]ZnO − 0.12CaO-xGa2O3, x = 0, 0.8, 0.16) was developed to formulate a series of Ga-containing glass polyalkenoate cements (GPCs). The solubility of GPCs was tested using DI water, and it was found that the sample containing the highest mol% of Ga, LGa-2, had the most Ga ion release. The GPCs were incubated in SBF, and SEM/EDS analysis revealed that the at% of P increased, while the at% of Si decreased, highlighting the CaP precipitation on the GPC surface. The at% of Ga also decreased, reinforcing the Ga release from the GPC. Cellular testing against fibroblasts and osteoblasts showed that a concentration of 25 mg/mL of the liquid extracts from the LGa-2 GPC had increased cell viability compared to other concentrations and GPCs tested. Antibacterial studies against E. coli and S. epidermidis demonstrated inhibition zones around the GPCs, highlighting their effectiveness in the elimination of bacteria on contact.
Recommended Citation
L. M. Placek et al., "Gallium-Containing Bioactive Glasses: Their Influence on Ion Release and the Bioactivity of Resulting Glass Polyalkenoate Cements," Applied Sciences Switzerland, vol. 15, no. 14, article no. 7756, MDPI, Jul 2025.
The definitive version is available at https://doi.org/10.3390/app15147756
Department(s)
Chemical and Biochemical Engineering
Publication Status
Open Access
Keywords and Phrases
bioactive glass; cell culture; gallium; glass polyalkenoate cement
International Standard Serial Number (ISSN)
2076-3417
Document Type
Article - Journal
Document Version
Final Version
File Type
text
Language(s)
English
Rights
© 2025 The Authors, All rights reserved.
Creative Commons Licensing
This work is licensed under a Creative Commons Attribution 4.0 License.
Publication Date
01 Jul 2025
