2.44 - the Aging Cochlea

Abstract

Age-related hearing loss (ARHL) – presbycusis—is a highly prevalent neurodegenerative and communication disorder. Progress has been made for understanding perceptual declines and biological bases of ARHL in human and animal model research. Loss of sound sensitivity, and deficits in complex processing including speech, are perceptual hallmarks of ARHL. Loss or damage to cochlear cells, including hair cells, stria vascularis cells and auditory nerve fibers are important structural changes. Disruptions of antioxidant and neurotransmitter systems occur, along with upregulation of apoptotic pathways. Clinically, presbycusis is not treatable; but as our understanding of the biological bases progresses, successful biomedical interventions will emerge.

Department(s)

Chemical and Biochemical Engineering

Keywords and Phrases

8th Nerve; Age-related hearing loss; Auditory hormone therapies; Auditory nerve fibers; Augmented acoustic environment; Cochlea therapies; Ear hydrogels; Hair cells; Hearing; Inner ear; Stria vascularis

International Standard Book Number (ISBN)

978-012805409-3;978-012805408-6

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2024 Elsevier, All rights reserved.

Publication Date

01 Jan 2020

Link to Full Text

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