Abstract
The slow accumulation of inflammatory biomarker levels in the body—also known as inflammation—has been linked to a myriad of age-related diseases. Some of these include neurodegenerative conditions such as Parkinson's disease, obesity, type II diabetes, cardiovascular disease, and many others. Though a direct correlation has not been established, research connecting age-related hearing loss (ARHL)—the number one communication disorder and one of the most prevalent neurodegenerative diseases of our aged population—and inflammation has gained interest. Research, thus far, has found that inflammatory markers, such as IL-6 and white blood cells, are associated with ARHL in humans and animals. Moreover, studies investigating ion channels and mitochondrial involvement have shown promising relationships between their functions and inflammation in the cochlea. In this review, we summarize key findings in inflammation within the auditory system, the involvement of ion channels and mitochondrial functions, and lastly discuss potential treatment options focusing on controlling inflammation as we age.
Recommended Citation
P. Bazard and J. Pineros and R. D. Frisina and M. A. Bauer and A. A. Acosta and L. R. Paganella and D. Borakiewicz and M. Thivierge and F. L. Mannering and X. Zhu and B. Ding, "Cochlear Inflammaging in Relation to Ion Channels and Mitochondrial Functions," Cells, vol. 10, no. 10, article no. 2761, MDPI, Oct 2021.
The definitive version is available at https://doi.org/10.3390/cells10102761
Department(s)
Chemical and Biochemical Engineering
Publication Status
Open Access
Keywords and Phrases
Age-related hearing loss; Aging; Auditory system; Cochlea; Inflammaging
International Standard Serial Number (ISSN)
2073-4409
Document Type
Article - Journal
Document Version
Final Version
File Type
text
Language(s)
English
Rights
© 2024 The Authors, All rights reserved.
Creative Commons Licensing
This work is licensed under a Creative Commons Attribution 4.0 License.
Publication Date
01 Oct 2021
PubMed ID
34685743
Comments
National Institutes of Health, Grant P01 AG009524