Modeling of the Primary and Secondary Drying Stages of the Freeze Drying of Pharmaceutical Products in Vials: Numerical Results Obtained from the Solution of a Dynamic and Spatially Multi-Dimensional Lyophilization Model for Different Operational Policies
Abstract
A rigorous unsteady state and spatially multidimensional model is presented and solved to describe the dynamic behavior of the primary and secondary drying stages of the lyophilization of a pharmaceutical product in vials for different operational policies. the results in this work strongly motivate the aggressive control of freeze drying and it is found that heat input control that runs the process close to the melting and scorch temperature constraints yields (i) faster drying times, and (ii) more uniform distributions of temperature and concentration of bound water at the end of the secondary drying stage. a rigorous unsteady state and spatially multidimensional model is presented and solved to describe the dynamic behavior of the primary and secondary drying stages of the lyophilization of a pharmaceutical product in vials for different operational policies. the results in this work strongly motivate the aggressive control of freeze drying and it is found that heat input control that runs the process close to the melting and scorch temperature constraints yields (i) faster drying times, and (ii) more uniform distributions of temperature and concentration of bound water at the end of the secondary drying stage.
Recommended Citation
P. P. Sheehan and A. I. Liapis, "Modeling of the Primary and Secondary Drying Stages of the Freeze Drying of Pharmaceutical Products in Vials: Numerical Results Obtained from the Solution of a Dynamic and Spatially Multi-Dimensional Lyophilization Model for Different Operational Policies," Biotechnology and Bioengineering, Wiley-Blackwell, Dec 1998.
The definitive version is available at https://doi.org/10.1002/(SICI)1097-0290(19981220)60:6<712::AID-BIT8>3.0.CO;2-4
Department(s)
Chemical and Biochemical Engineering
Sponsor(s)
University of Missouri--Rolla. Biochemical Processing Institute
Jefferson Smurfit Fellowship
Keywords and Phrases
Distribution of Bound Water; Freeze Drying in Vials; Lyophilization in Vials; Surface Geometry of Moving Interface; Velocity of Moving Interface
International Standard Serial Number (ISSN)
0006-3592
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 1998 Wiley-Blackwell, All rights reserved.
Publication Date
01 Dec 1998
