Abstract
The results obtained from the pore network model employed in this work, clearly show that the magnitudes of the intraparticle electroosmotic volumetric flowrate, Q(intrap), and velocity, < v (intrap,x) >, in the pores of the charged porous silica particles considered in this study are greater than zero. The intraparticle Peclet number, Pe(intra), of a solute in these charged porous silica particles would be greater than zero, and, in fact, the magnitude of the intraparticle Peclet number, Pe(intrap), of lysozyme is greater than unity for all the values of the pore connectivity, n(T), of the intraparticle pores and of the applied electric potential difference per unit length, E(x), along the axis of the capillary column considered in this work. Furthermore, the values of the intraparticle electroosmotic volumetric flow- rate, Q(intrap), and velocity, < v (intrap,x) >, as well as the magnitude of the pore diffusion coefficient, D(p), of the solute increase as the value of the pore connectivity, n(T), of the intraparticle pores increases. The intraparticle electroosmotic flow can contribute significantly, if the appropriate chemistry is employed in the mobile liquid phase and in the charged porous particles, in (i) decreasing the intraparticle mass transfer resistance, (ii) decreasing the dispersive mass transfer effects, and (iii) increasing the intraparticle mass transfer rates so that high column efficiency and resolution can be obtained. (C) 2000 Elsevier Science B.V.
Recommended Citation
B. A. Grimes et al., "Determination of the Intraparticle Electroosmotic Volumetric Flow-rate, Velocity and Peclet Number in Capillary Electrochromatography from Pore Network Theory," Journal of Chromatography A, vol. 890, no. 1, pp. 61 - 72, Elsevier, Aug 2000.
The definitive version is available at https://doi.org/10.1016/S0021-9673(00)00130-8
Department(s)
Chemical and Biochemical Engineering
Keywords and Phrases
Electrochromatography; Electroosmotic flow; Intraparticle electroosmotic velocity; Intraparticle flow; Mathematical modeling; Peclet number; Pore diffusion coefficient; Pore network model
International Standard Serial Number (ISSN)
0021-9673
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2024 Elsevier, All rights reserved.
Publication Date
18 Aug 2000
PubMed ID
10976795
