Abstract

In this work, a mathematical model is constructed and solved to describe the propagation and dispersion of the mass wave of an analyte in a capillary electrochromatography (CEC) column packed with porous adsorbent particles and operated in the analytical mode. The evolution and dynamic behavior of the isoconcentration contours of the concentration of the analyte in the pores of the particles are presented in order to demonstrate the significant impact that the velocity of the intraparticle electroosmotic flow (EOF) encountered in CEC systems could have in reducing the overall intraparticle mass transfer resistance. It is shown that under both unretained and retained conditions the intraparticle EOF causes a significant departure in the spherical symmetry of the isoconcentration contours of an analyte in the pores of spherical porous adsorbent particles. The asymmetric isoconcentration contours clearly indicate how the intraparticle EOF leads to highly resolved and evenly distributed mass waves of an analyte in the effluent stream of the CEC column and provide efficient separation performance. Furthermore, comments are presented that describe the conditions that could be encountered in CEC systems which could significantly increase the overall intraparticle mass transfer resistance as well as the mass transfer resistance in the interstitial channels for bulk flow and lead to inefficient separation performance.

Department(s)

Chemical and Biochemical Engineering

Publication Status

Full Access

Keywords and Phrases

Capillary electrochromatography; Charged porous adsorbent particles; Intraparticle electroosmotic fluid flow; Intraparticle isoconcentration contours; Intraparticle pore diffusion

International Standard Serial Number (ISSN)

1615-9306

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2024 Wiley-VCH Verlag; Wiley, All rights reserved.

Publication Date

01 Dec 2002

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