Effect Of Liquid Environment On Adhesion Strength Of Bioactive Glass-based Adhesives To Bone

Abstract

Glass Polyalkenoate Cements (GPCs) are composed of ionomeric glass having setting reaction with aqueous poly(acrylic) acid (PAA). The mechanical properties of GPCs are normally affected by various factors such as the concentration of the acid solution, the molar mass of the polyacid, and the powder:liquid ratio. A previous study using fracture testing of double cantilever beam specimens made with a GPC (GPC A) adhered to bovine bone showed that the mode I energy release rate decreased significantly when the specimens were prepared in a flooded liquid environment, simulating a worst-case surgical sternal closure application. The present study used pull-out and butt strength tests to determine the extent to which the adhesion to bovine bone could be improved in wet environments by using a more viscous adhesive (GPC B). The pull-out samples were prepared in both dry and flooded liquid environments and incubated in both humid and flooded liquid environments at 37 °C for two time periods: one and seven days. Overall, the pull-out strength of GPC B was found to be between 56% and 808% higher than GPC A, indicating that the more viscous formulation could mitigate the effects of the wet environment. The GPC B samples prepared and incubated in a flooded liquid environment (L-LI) had a significantly lower pull-out strength than all three other conditions: (1) when prepared in a dry environment and incubated in either a liquid (D-LI) or (2) humid environment (D-H), and (3) when prepared in a liquid environment and incubated in a humid one (L-H), which were all of similar strength. No significant difference in pull-out strength between the samples tested after 1 and 7 days of incubation was found indicating that robust adhesion strength was obtained rapidly. To further assess the adhesive strength for augmenting sternal closure, GPC B and bovine bone were used to create butt joints which were tested at strain rates typical of breathing and coughing. The tests revealed that GPC B's viscoelastic properties resulted in a higher butt joint strength for coughing loads compared to breathing. Overall, the results of the present study show that when the adhesives are expected to be subjected to a flooded liquid environment while they set, significant gains in adhesive strength can be obtained by using more viscous GPC adhesives.

Department(s)

Chemical and Biochemical Engineering

Comments

Canadian Institutes of Health Research, Grant 356780-DAN

Keywords and Phrases

Bone cement; Butt joint testing; Glass polyalkenoate cement; Pull-out; Sternotomy; Sternum fixation

International Standard Serial Number (ISSN)

0143-7496

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2023 Elsevier, All rights reserved.

Publication Date

01 Aug 2023

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