Freeze Drying Of A Frozen Liquid In A Phial

Author

Athanasios I. Liapis, Missouri University of Science and TechnologyFollow
J. M. Marchello, Missouri University of Science and Technology

Abstract

A sorption-sublimation mathematical model for a freeze dryer is presented, and is used to investigate the design and operation of a freeze dryer, in which a frozen liquid enclosed in a phial is dried.With the material chosen, it was found that the best operating condition would correspond to minimum chamber inert gas pressure. The most desirable design of dryer appears to be one in which moderate but consistent resistances to heat transfer are incorporated, so that the heat flux program of the lower heating plate could be optimized by operating at a higher temperature, either under feedback or pre-programed feedforward controllers. © 1983, Taylor & Francis Group, LLC. All rights reserved.

Recommended Citation

A. I. Liapis and J. M. Marchello, "Freeze Drying Of A Frozen Liquid In A Phial," Drying Technology, vol. 2, no. 2, pp. 203 - 217, Taylor and Francis Group; Taylor and Francis, Jan 1983.

The definitive version is available at https://doi.org/10.1080/07373938308959825

Department(s)

Chemical and Biochemical Engineering

Keywords and Phrases

Biologicals; controllers; heat flux; pressure; sorption; sublimation; thermal resistance; vapor

International Standard Serial Number (ISSN)

1532-2300; 0737-3937

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2023 Taylor and Francis Group; Taylor and Francis, All rights reserved.

Publication Date

01 Jan 1983