Abstract
The freeze‐drying process is studied under various operational policies through the use of a sorption‐sublimation model. The operational policy that provides the shortest drying times keeps the pressure at its lowest value. The upper and lower heating plates are independently controlled so that the material constraints are encountered and held throughout the free water removal phase. Under certain conditions, and for the case of samples of small thickness, the sorbed water profiles may have segments whose bound water concentrations are higher than those at the start of the free water removal phase. It is shown that the criterion used in terminating the freeze‐drying process is of extreme importance, since it may lead to an undesirable sorbed water profile which may deteriorate the quality of the dried product. Copyright © 1985 American Institute of Chemical Engineers
Recommended Citation
M. J. Millman et al., "An Analysis Of The Lyophilization Process Using A Sorption‐sublimation Model And Various Operational Policies," AIChE Journal, vol. 31, no. 10, pp. 1594 - 1604, Wiley; American Institute of Chemical Engineers (AIChE), Jan 1985.
The definitive version is available at https://doi.org/10.1002/aic.690311003
Department(s)
Chemical and Biochemical Engineering
Publication Status
Full Access
International Standard Serial Number (ISSN)
1547-5905; 0001-1541
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2023 Wiley; American Institute of Chemical Engineers (AIChE), All rights reserved.
Publication Date
01 Jan 1985
