The Processing, Mechanical Properties and Bioactivity of Strontium based Glass Polyalkenoate Cements
Abstract
The suitability of zinc-based glass polyalkenoate cements (GPCs) for use in orthopaedics can be improved by the substitution of strontium into the glass phase which should impart improved radiopacity and bone forming properties to the cements without retarding strength. The purpose of this research was to produce novel GPCs based on calcium-strontium-zinc-silicate glasses and to evaluate their mechanical properties and biocompatibility with the ultimate objective of developing a new range of cements for skeletal applications. Three glass compositions, based on incremental substitutions of strontium for calcium, were synthesized; BT100 (0.16CaO, 0.36ZnO, 0.48SiO2), BT101 (0.04SrO, 0.12CaO, 0.36ZnO, 0.48SiO2) and BT102 (0.08SrO 0.08CaO, 0.36ZnO, 0.48SiO2). Each glass was then mixed with varying concentrations and molecular weights of polyacrylic acids in order to determine the working times, setting times, compressive strengths and biaxial flexural strengths of the novel cements. The maximum working time and setting time achieved was 29 and 110 s respectively; which, at present is inadequate for current clinical procedures. However, the optimum compressive and biaxial flexural strengths were up to 75 and 34 MPa respectively indicating that these formulations have potential in load bearing applications. Importantly, the substitution of Ca with Sr in the glasses did not have a deleterious effect on strengths or working times. Finally, the bioactivity of the best performing cements was determined in vitro using simulated body fluid. It was found that all cements facilitate the formation of an amorphous calcium phosphate at their surface which increases in density and coverage with time, indicating that these cement will bond directly to bone in vivo. © 2007 Springer Science+Business Media, LLC.
Recommended Citation
A. Wren et al., "The Processing, Mechanical Properties and Bioactivity of Strontium based Glass Polyalkenoate Cements," Journal of Materials Science: Materials in Medicine, vol. 19, no. 4, pp. 1737 - 1743, Springer, Apr 2008.
The definitive version is available at https://doi.org/10.1007/s10856-007-3287-z
Department(s)
Chemical and Biochemical Engineering
International Standard Serial Number (ISSN)
0957-4530
Document Type
Article - Conference proceedings
Document Version
Final Version
File Type
text
Language(s)
English
Rights
© 2023 The Authors, All rights reserved.
Creative Commons Licensing
This work is licensed under a Creative Commons Attribution 4.0 License.
Publication Date
01 Apr 2008
PubMed ID
17943414
Included in
Biochemical and Biomolecular Engineering Commons, Biomedical Devices and Instrumentation Commons
Comments
Enterprise Ireland, Grant /2005/327