Comparison of in Vitro and in Vivo Bioactivity of SrO-CaO-ZnO-SiO2 Glass Grafts
Abstract
A range of calcium-strontium-zinc-silicate glass grafts are developed. Following characterization, their ability to form an apatite layer in simulated body fluid (SBF) is evaluated. Concurrently, their in vivo biocompatibility is determined. These glasses are incapable of forming an apatite layer in SBF. However, in vivo, each glass is well tolerated with new bone formation apparent in close apposition to implanted particles and no evidence of an inflammatory response. Such results are contrary to much of the literature and indicate that forecasting a materials ability to bond to bone based on SBF experiments may provide a false negative result. © SAGE Publications, Inc. 2009.
Recommended Citation
M. R. Towler et al., "Comparison of in Vitro and in Vivo Bioactivity of SrO-CaO-ZnO-SiO2 Glass Grafts," Journal of Biomaterials Applications, vol. 23, no. 6, pp. 561 - 572, SAGE Publications, May 2009.
The definitive version is available at https://doi.org/10.1177/0885328208094306
Department(s)
Chemical and Biochemical Engineering
International Standard Serial Number (ISSN)
1530-8022; 0885-3282
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2023 SAGE Publications, All rights reserved.
Publication Date
19 May 2009
PubMed ID
18757496
