Abstract
Many commercial bone grafts cannot regenerate healthy bone in place of diseased bone. Bioactive glasses have received much attention in this regard due to the ability of their ionic dissolution products to promote cell proliferation, cell differentiation and activate gene expression. Through the incorporation of certain ions, bioactive glasses can become therapeutic for specific pathological situations. Calcium-strontium-sodium-zinc-silicate glass bone grafts have been shown to release therapeutic levels of zinc and strontium, however the in vitro compatibility of these materials is yet to be reported. In this study, the in vitro cytocompatibility of three different calcium-strontium-sodium-zinc-silicate glasses was examined as a function of their ion release profiles, using Novabone® bioglass as a commercial comparison. Experimental compositions were shown to release Si4+ ranging from 1 to 81 ppm over 30 days; comparable or enhanced release in comparison to Novabone. The maximum Ca2+ release detected for experimental compositions was 9.1 ppm, below that reported to stimulate osteoblasts. Sr2+ release was within known therapeutic ranges, and Zn2+ release ranged from 0.5 to 1.4 ppm, below reported cytotoxic levels. All examined glass compositions show equivalent or enhanced in vitro compatibility in comparison to Novabone. Cells exposed to BT112 ionic products showed enhanced cell viabilities indicating cell proliferation was induced. The ion release profiles suggest this effect was due to a synergistic interaction between certain combinations and concentrations of ions. Overall, results indicate that the calcium-strontium-sodium-zinc-silicate glass compositions show equivalent or even enhanced in vitro compatibility compared to Novabone®. © 2010 Springer Science+Business Media, LLC.
Recommended Citation
S. Murphy et al., "The Effect of Ionic Dissolution Products of Ca-Sr-Na-Zn-Si Bioactive Glass on in Vitro Cytocompatibility," Journal of Materials Science: Materials in Medicine, vol. 21, no. 10, pp. 2827 - 2834, Springer, Oct 2010.
The definitive version is available at https://doi.org/10.1007/s10856-010-4139-9
Department(s)
Chemical and Biochemical Engineering
International Standard Serial Number (ISSN)
0957-4530
Document Type
Article - Journal
Document Version
Final Version
File Type
text
Language(s)
English
Rights
© 2023 The Authors, All rights reserved.
Creative Commons Licensing
This work is licensed under a Creative Commons Attribution 4.0 License.
Publication Date
01 Oct 2010
PubMed ID
20711638
Included in
Biochemical and Biomolecular Engineering Commons, Biomedical Devices and Instrumentation Commons
