Biological Evaluation of Nano-Hydroxyapatite-Zirconia (HA-ZrO2) Composites and Strontium-Hydroxyapatite (Sr-HA) for Load-Bearing Applications
Abstract
The biological response of strontium (Sr) doped hydroxyapatite (HA) and hydroxyapatite-zirconia (HA-ZrO2) composites produced by employing sol-gel technology, minimal ZrO2 loadings, and novel microwave-sintering regimes thereby retarding decomposition, is reported. In vitro evaluations indicate that all materials induce a favorable response from rat osteosarcoma cells. In vivo evaluations show osteoconductivity and biocompatibility for both the Sr-HA and HA-ZrO2. The materials did not cause any inflammatory response in bone. The Sr-HA displays better biocompatibility which may be due to the incorporation of Sr and the formation of a surface apatite layer. © The Author(s) 2011.
Recommended Citation
I. Brook et al., "Biological Evaluation of Nano-Hydroxyapatite-Zirconia (HA-ZrO2) Composites and Strontium-Hydroxyapatite (Sr-HA) for Load-Bearing Applications," Journal of Biomaterials Applications, vol. 27, no. 3, pp. 291 - 298, SAGE Publications, Sep 2012.
The definitive version is available at https://doi.org/10.1177/0885328211403020
Department(s)
Chemical and Biochemical Engineering
International Standard Serial Number (ISSN)
1530-8022; 0885-3282
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2023 SAGE Publications, All rights reserved.
Publication Date
01 Sep 2012
PubMed ID
21926146
