Abstract
Silver (Ag) coated bioactive glass particles (Ag-BG) were formulated and compared to uncoated controls (BG) in relation to glass characterization, solubility and microbiology. X-ray diffraction (XRD) confirmed a crystalline AgNP surface coating while ion release studies determined low Ag release (/L). Cell culture studies presented increased cell viability (127 and 102%) with lower liquid extract (50 and 100 ml/ml) concentrations. Antibacterial testing of Ag-BG in E. coli, S. epidermidis and S. aureus significantly reduced bacterial cell viability by 60-90%. Composites of Ag-BG/CMC-Dex Hydrogels were formulated and characterized. Agar diffusion testing was conducted where Ag-BG/hydrogel composites produced the largest inhibition zones of 7 mm (E. coli), 5 mm (S. aureus) and 4 mm (S. epidermidis). This study presents the synthesis of AgNP coated bioactive glass particles which are incorporated into Dex/CMC hydrogels for localized therapeutic effects. Solubility profiles are determined in addition to evaluating toxicity levels in eukaryotic cells. Additionally, antibacterial properties are evaluated in microbes such as S. aureus, E. coli, and S. epidermidis.
Recommended Citation
A. W. Wren et al., "Silver Nanoparticle Coated Bioactive Glasses - Composites with Dex/CMC Hydrogels: Characterization, Solubility, and in Vitro Biological Studies," Macromolecular Bioscience, vol. 15, no. 8, pp. 1146 - 1158, Wiley, Aug 2015.
The definitive version is available at https://doi.org/10.1002/mabi.201500109
Department(s)
Chemical and Biochemical Engineering
International Standard Serial Number (ISSN)
1616-5195; 1616-5187
Document Type
Article - Journal
Document Version
Final Version
File Type
text
Language(s)
English
Rights
© 2023 Wiley, All rights reserved.
Publication Date
01 Aug 2015
PubMed ID
25923463
Included in
Biochemical and Biomolecular Engineering Commons, Biomedical Devices and Instrumentation Commons
