Abstract
Bioactive glasses may function as antimicrobial delivery systems through the incorporation and subsequent release of therapeutic ions. The aim of this study was to evaluate the antimicrobial properties of a series of composite scaffolds composed of poly (octanediol citrate) with increased loads of a bioactive glass that releases zinc (Zn2+) and gallium (Ga3+) ions in a controlled manner. The antibacterial activity of these scaffolds was investigated against both Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. The ability of the scaffolds to release ions and the subsequent ingress of these ions into hard tissue was evaluated using a bovine bone model. Scaffolds containing bioactive glass exhibited antibacterial activity and this increased in vitro with higher bioactive glass loads; viable cells decreased to about 20 % for the composite scaffold containing 30 % bioactive glass. The Ga3+ release rate increased as a function of time and Zn2+ was shown to incorporate into the surrounding bone.
Recommended Citation
E. Zeimaran et al., "Antibacterial Properties of Poly (Octanediol Citrate)/gallium-Containing Bioglass Composite Scaffolds," Journal of Materials Science: Materials in Medicine, vol. 27, no. 1, pp. 1 - 11, article no. 18, Springer, Jan 2016.
The definitive version is available at https://doi.org/10.1007/s10856-015-5620-2
Department(s)
Chemical and Biochemical Engineering
International Standard Serial Number (ISSN)
1573-4838; 0957-4530
Document Type
Article - Journal
Document Version
Final Version
File Type
text
Language(s)
English
Rights
© 2023 The Authors, All rights reserved.
Creative Commons Licensing
This work is licensed under a Creative Commons Attribution 4.0 License.
Publication Date
01 Jan 2016
PubMed ID
26676864
Included in
Biochemical and Biomolecular Engineering Commons, Biomedical Devices and Instrumentation Commons
