Abstract
Synthesis and characterization of the first mesoporous bioactive glasses (MBGs) containing tantalum are reported here, along with their potential application as hemostats. Silica MBGs were synthesized using with the molar composition of (80-x)% Si, 15% Ca, 5% P, and x% Ta. It was found that incorporation of >1 mol % Ta into the MBGs changes their physical and chemical properties. Increasing Ta content from 0 to 10 mol % causes a decrease in the surface area and pore volume of ~20 and ~35%, respectively. This is due to the increase in nonbridging oxygens and mismatch of thermal expansion coefficient which created discontinuities in the ordered channel structure. However, the effect is not significant on the amount of ions (Si, Ca, P, and Ta) released, from the sample into deionized water, for short durations (<60 >min). In a mouse tail-cut model, a significant decrease in bleeding time (≥50% of average bleeding time) was found for Ta-MBGs compared to having no treatment, Arista, and MBG without Ta. Further studies are proposed to determine the mechanism of Ta involvement with the hemostatic process. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2229–2237, 2019.
Recommended Citation
A. Mendonca et al., "The Effect of Tantalum Incorporation on the Physical and Chemical Properties of Ternary Silicon–calcium–phosphorous Mesoporous Bioactive Glasses," Journal of Biomedical Materials Research - Part B Applied Biomaterials, vol. 107, no. 7, pp. 2229 - 2237, Wiley, Oct 2019.
The definitive version is available at https://doi.org/10.1002/jbm.b.34310
Department(s)
Chemical and Biochemical Engineering
International Standard Serial Number (ISSN)
1552-4981; 1552-4973
Document Type
Article - Journal
Document Version
Final Version
File Type
text
Language(s)
English
Rights
© 2023 Wiley, All rights reserved.
Publication Date
01 Oct 2019
PubMed ID
30676687
Included in
Biochemical and Biomolecular Engineering Commons, Biomedical Devices and Instrumentation Commons
