Abstract
A titanium-containing borate glass series based on the system (52-X) B2O3–12CaO–6P2O5–14Na2O–16ZnO-XTiO2 with X varying from 0, 5 and 15 mol% of TiO2 incorporated, identified as BRT0, BRT1 and BRT3, respectively, were used in this study. Scaffolds (pore sizes, 165–230 μm and porosity, 53.51–69.51%) were prepared using a polymer foam replication technique. BRT3 scaffolds exhibited higher compressive strength (7.16 ± 0.22 MPa) when compared to BRT0 (6.02 ± 0.47 MPa) and BRT1 (5.65 ± 0.28 MPa) scaffolds with lower, or no, TiO2 content. The solubility of the scaffolds decreased as the TiO2 content increased up to 15 mol% when samples of each scaffold were immersed in DI water and the pH of all these extracts went up from 7.0 to 8.5 in 30 days. The cumulative ion release from the scaffolds showed significant difference with respect to TiO2 content; addition of 5 mol% TiO2 at the expense of borate (B2O3) decreased the ion release remarkably. Furthermore, it was found that for all three scaffolds, cumulative ion release increased with incubation time. The results indicate that the degradation rates and compressive strengths of borate bioactive glass scaffolds could be controlled by varying the amount of TiO2 incorporated, confirming their potential as scaffolds in TKA and rTKA.
Recommended Citation
R. Shafaghi et al., "Effect of TiO2 Doping on Degradation Rate, Microstructure and Strength of Borate Bioactive Glass Scaffolds," Materials Science and Engineering C, vol. 107, article no. 110351, Elsevier, Feb 2020.
The definitive version is available at https://doi.org/10.1016/j.msec.2019.110351
Department(s)
Chemical and Biochemical Engineering
International Standard Serial Number (ISSN)
1873-0191; 0928-4931
Document Type
Article - Journal
Document Version
Final Version
File Type
text
Language(s)
English
Rights
© 2023 Elsevier, All rights reserved.
Publication Date
01 Feb 2020
PubMed ID
31761236
Included in
Biochemical and Biomolecular Engineering Commons, Biomedical Devices and Instrumentation Commons
